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Cajun Butter baked salmon on a white plate with vegetables cooked on the same sheetpan
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4.88 from 8 votes

Cajun Baked Salmon

A cajun baked salmon with a cajun butter sauce. This filet of salmon is rich and flavorful and cooked on a sheet pan with vegetables for a complete meal.
Prep Time10 minutes
Cook Time10 minutes
Total Time20 minutes
Course: Main Dish
Cuisine: American
Keyword: baked salmon, cajun, cajun salmon, coho salmon
Servings: 6
Calories: 456kcal


  • 2 lb fillet of PrimeWaters Seafood Coho Salmon
  • 1 Tbs Olive oil

Cajun Seasoning

  • 2 tablespoons garlic powder
  • 2 tablespoons Italian seasoning
  • 2 tablespoons paprika
  • 2 tablespoons salt
  • 1 tablespoon black pepper
  • 1 1/2 tablespoon cayenne pepper
  • 1 tablespoon thyme
  • 1 tablespoon onion powder

Cajun Butter Sauce

  • 1/2 cup butter
  • 1/2 Tablespoon Minced Garlic
  • 1 Tablespoon Cajun seasoning from above
  • 1 cup roasted red peppers
  • 1/4 cup celery
  • 1/2 lemon juiced


  • 1 Tbs olive oil
  • 1 lb Asparagus
  • 2 cups zucchini chopped


Cajun Seasoning

  • Combine all seasoning ingredients together in a bowl and whisk together, set aside.


  • Turn oven on to the broil setting on high to preheat.
  • Let salmon rest on the counter for 15-30 minutes to come up to room temperature.
  • Place Coho Salmon fillet skin-side-down on a baking sheet. If the ends of the salmon filet are thin, tuck them under for more even cooking.
  • Pat Salmon dry with a paper towel, then brush olive oil over the top. Generously season with Cajun seasoning mixture (use about 1/4 a cup, less if you don't like a lot of seasoning).  Set aside. 
  • Vegetables
  • Clean vegetables and chop zucchini. Snap the rough ends off asparagus.
  • Toss vegetables with 1 Tbs cajun seasoning mixture and 1 Tbs olive oil and place around the salmon filet on the sheet pan.
  • Cook in Oven set to Broil for 10-14 minutes, until Salmon is cooked through and vegetables are tender. Internal temperature of the salmon should reach 135-140°F

Cajun Butter Sauce

  • While salmon and vegetables bake, add all of the cajun butter sauce ingredients into a medium sized saucepan except the lemon juice, and bring to a boil with medium high heat.
  • Once boiling, use a stick blender to blend until smooth. Or pour into a blender and blend until smooth.
  • Taste, and add lemon juice to preference.
  • Carefully spoon cajun butter sauce over salmon, and serve!


The FDA recommends cooking salmon to an internal temperature of 145°F. This is measured in the thickest part of the salmon. 


Calories: 456kcal | Carbohydrates: 13g | Protein: 34g | Fat: 30g | Saturated Fat: 12g | Cholesterol: 123mg | Sodium: 2861mg | Potassium: 1248mg | Fiber: 5g | Sugar: 3g | Vitamin A: 3655IU | Vitamin C: 30.5mg | Calcium: 113mg | Iron: 5.2mg